In this paper, a heterogeneous diffusive pc381ls prey-predator system is first proposed and then studied analytically and numerically.Some sufficient conditions are derived, including permanence and extinction of system and the boundedness of the solution.The existence of periodic solution and its stability are discussed as well.Furthermore, numerical results indicate that both the spatial heterogeneity and the time-periodic environment can influence the permanence and extinction of the system directly.Our mg09aca18te numerical results are consistent with the analytical analysis.